Trend of fertility potentials with increasing age in Pakistani males

The objective being to examine the magnitude and the shape of the relationships between age and semen volume, sperm concentration and sperm motility by keeping the other factors affecting fertility directly constant among patients undergoing infertility evaluation at National Institute of Health, Islamabad, Pakistan. This experimental study with non-probability sampling was conducted in Reproductive Physiology/Health, Public Health Laboratories Division, National Institute of Health, Islamabad during 2006-2009. A total 350 patients [21-50 years] were divided age wise into three groups [21-30, 31-40 and 41-50 years] to compare alteration in sperm count and motility. Semen profile was evaluated according to WHO reference value for normal semen characteristics. The result of Sperm concentration showed a non significant [p>0.05] decreasing trend with increasing age that was 0.047million/ml for every year where as sperm motility declined significantly with increasing age at p>0.05. Age-related decreases in semen qualities particularly decline in sperm motility revealed that men may become progressively less fertile as they age. However, unlike women, there appears to be no evidence of an age threshold for men

Prevalence of hyperprolactinemia in different age groups of women with fertility problems

Hormonal disturbance is one of the major causes of infertility and higher prolactin concentration, causes ovulatory dysfunction and infertility in women. Aim of our study was the evaluation of disordered prolactin concentration for fertility related complaints in female patients and prevalence of hyperprolactinemia in various age groups. The study was carried out in Reproductive Physiology/Health, PHLD NIH [National Institute of Health, Islamabad]. 246 women complaining fertility problems were included in study. Subjects were divided into two major groups ranging from 13-50 years [n=165] in Normal and 13-40 years [n=81] in Hyperprolactinemic group where Normal group had reference value of 1.9-25.9 ng/ml and Hyperprolactinemic group was having prolactin level >25.9 ng/ml. They were further sub-divided into age groups, four groups in Normal category and three groups in Hyperprolactinemic category. 66% women in all had serum concentration of prolactin in normal limits [1.9-25.9 ng/ml] whereas 33% women had elevated prolactin level. The mean serum concentration of prolactin Hyperprolactinemic groups [in each age group] varied significantly from Normal groups [P<0.01]. Decrease in prolactin level was seen in advancing age